Chitosan/vancomycin antibacterial hydrogel for application in knee prostheses
نویسندگان
چکیده
Chitosan hydrogels stand out for being an adhesive matrix, which presents biocompatibility, antibacterial and osteogenic properties, biodegradability, non-toxicity, capable of retaining, releasing, distributing therapeutic agents (drugs) at the application site. Therefore, new strategies in field orthopedics have focused, above all, on limiting initial preoperative postoperative microbial adhesion to implant surfaces, modifying these protecting them from eventual adhesions or releasing antimicrobial agent. The production chitosan-based has been achieved through physical chemical cross-linking routes. In this context, research aimed develop hydrogel based chitosan vancomycin total knee arthroplasty prevent bacterial infections. For that, three crosslinking procedures with genipin were investigated obtain drug delivery. purpose, initially, raw materials chitosan, characterized by infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray diffraction (XRD), pHmetry (pH) microbiological tests. From evaluated, release was investigated, FTIR, pH, viscosity, microbiology, cytotoxicity. A H5Q1GV obtained good activity, potentiated acidity its pH 5.7, showed first 4 hours after implantation, homogeneous, ideal viscosity syringes prosthesis surgery. excellent biocompatibility.
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ژورنال
عنوان ژورنال: Research, Society and Development
سال: 2022
ISSN: ['2525-3409']
DOI: https://doi.org/10.33448/rsd-v11i3.26646